Pharmacological studies on 5-hydroxy-L-tryptophan (L-5HTP)
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منابع مشابه
Nocturnal plasma levels of melatonin in quails (Coturnix japonica) injected with l-5-hydroxy-tryptophan.
This study aimed to demonstrate the influence of the systemic administration of l-5-hydroxy-tryptophan (L-HTP) on the plasma levels of melatonin during the dark period in quails. Throughout daylight, the plasma levels of melatonin did not differ significantly, oscillating between 110.2 +/- 15.8 pg.mL(-1) and 157.4 +/- 34.8 pg.mL(-1), from 8 to 16 hours. L-HTP (25 mg.kg(-1), through the intracel...
متن کاملPrimary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
The efficacy and tolerability of 5-hydroxy-L-tryptophan (5-HTP) were studied in an open 90-day study in 50 patients affected by primary fibromyalgia syndrome. When all the clinical variables studied throughout the trial (number of tender points, anxiety, pain intensity, quality of sleep, fatigue) were compared with baseline results, they all showed a significant improvement (P less than 0.001)....
متن کامل5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats.
Giving L-tryptophan, serotonin's circulating precursor, or a serotonin-releasing drug can decrease food intake and body weight. Giving 5-hydroxy-L-tryptophan (5-HTP), serotonin's immediate intracellular precursor, has been thought to be ineffective in enhancing brain serotonin synthesis unless it is coadministered with a dopa decarboxylase inhibitor to protect 5-HTP from destruction outside the...
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塩屋 明利 ・倉石 弘一 ・柿本 守夫 ・玉真 洋子 In a healthy subject, ammonia produced in the body is excreted by the kidney in the form of urea, the product of the urea cycle (1), or converted into substances useful for the body. In cases of hepatic disorders, on the other hand, blood ammonia level is known to increase (2-6). It is likely that ammonia in high concentrations interferes with the TCA cycle (7) and th...
متن کاملThe antinatriuretic action of gamma-L-glutamyl-5-hydroxy-L-tryptophan is dependent on its decarboxylation to 5-hydroxytryptamine in normal man.
1. The effects of inhibition of peripheral aromatic L-amino acid decarboxylase during infusion of the relatively renally selective 5-hydroxytryptamine (5-HT) prodrug, gamma-L-glutamyl-5-hydroxy-L-tryptophan (glu-5-HTP), were examined in eight healthy male subjects in a randomised, placebo-controlled, cross-over study. 2. Each subject received oral carbidopa (100 mg) or placebo followed, 1 h lat...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1976
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.72.23